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Review
. 2008 Oct;5(4):516-27.
doi: 10.1016/j.nurt.2008.08.002.

ALS drug development: reflections from the past and a way forward

Swati Aggarwal  1 , Merit Cudkowicz
Affiliations
Review

ALS drug development: reflections from the past and a way forward

Swati Aggarwal et al. Neurotherapeutics. 2008 Oct.

Abstract

Tremendous advances in our understanding of pathogenesis of amyotrophic lateral sclerosis (ALS) have provided a rich pipeline of drugs for clinical trialists. At least 32 unique compounds have been tested. Nevertheless, riluzole is currently the only treatment that prolongs survival. We present a critical overview of past clinical trials, how therapies are selected for testing in people, challenges with ALS clinical trial design and conduct, and ways to best move forward.

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