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Review
. 2009 Feb 6;6(31):129-47.
doi: 10.1098/rsif.2008.0341.

Genome and proteome annotation: organization, interpretation and integration

Gabrielle A Reeves  1 , David Talavera, Janet M Thornton
Affiliations
Review

Genome and proteome annotation: organization, interpretation and integration

Gabrielle A Reeves et al. J R Soc Interface. .

Abstract

Recent years have seen a huge increase in the generation of genomic and proteomic data. This has been due to improvements in current biological methodologies, the development of new experimental techniques and the use of computers as support tools. All these raw data are useless if they cannot be properly analysed, annotated, stored and displayed. Consequently, a vast number of resources have been created to present the data to the wider community. Annotation tools and databases provide the means to disseminate these data and to comprehend their biological importance. This review examines the various aspects of annotation: type, methodology and availability. Moreover, it puts a special interest on novel annotation fields, such as that of phenotypes, and highlights the recent efforts focused on the integrating annotations.

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Figures

Figure 1
Figure 1
A selection of resources showing data for the human epidermal growth factor receptor (EGFR). (a) Ensembl (genomic information), (b) ASAP II (alternative splicing information), (c) Dasty2 protein DAS client (protein kinase domain), (d) InterProScan (functional annotation), (e) OMIM (disease information), (f) Reactome (EGFR signalling information): signalling by EGFR (Homo sapiens), (g) CATH domain database (protein kinase domain), (h) PDBsum (structural information) and (i) GO (MAP/ERK kinase kinase activity)
See this image and copyright information in PMC

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