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Case Reports
. 2008 Dec;86(6):e7-8.
doi: 10.1016/j.athoracsur.2008.07.062.

Sirolimus ameliorated post lung transplant chylothorax in lymphangioleiomyomatosis

Toshiaki Ohara  1 , Takahiro Oto, Kentaro Miyoshi, Hiroyuki Tao, Masaomi Yamane, Shinichi Toyooka, Megumi Okazaki, Hiroshi Date, Yoshifumi Sano
Affiliations
Case Reports

Sirolimus ameliorated post lung transplant chylothorax in lymphangioleiomyomatosis

Toshiaki Ohara et al. Ann Thorac Surg. 2008 Dec.

Abstract

We report a successful case of sirolimus treatment for chylous pleural and peritoneal effusions of lymphangioleiomyomatosis after lung transplantation. A 32-year-old woman underwent living donor lung transplantation. Persistent chylous pleural and peritoneal effusions were seen postoperatively. Pleurodesis by intrathoracic injection of OK-432, minomycin, and somatostatine analog failed to control chylous effusions. However, sirolimus treatment reduced the amount of chylous drainage and improved both chylous pleural and peritoneal effusions.

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