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Review
. 2008 Nov 24;15(11):1141-7.
doi: 10.1016/j.chembiol.2008.10.010.

N-Acylhomoserine lactone-mediated quorum sensing: a twist in the tail and a blow for host immunity

Margaret Cooley  1 , Siri Ram Chhabra, Paul Williams
Affiliations
Review

N-Acylhomoserine lactone-mediated quorum sensing: a twist in the tail and a blow for host immunity

Margaret Cooley et al. Chem Biol. .

Abstract

Communication through quorum sensing (QS) enables bacterial populations to coordinate their behavior. Recent work on N-acylhomoserine lactone-mediated QS has revealed that some soil bacteria exploit host-derived substrates to generate an alternative N-substituted homoserine lactone. New light has also been shed on the mechanism by which N-(3-oxo-dodecanoyl)-L-homoserine lactone modulates host inflammatory signaling pathways to promote bacterial survival.

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