Review
doi: 10.2337/diab.40.5.521.
Some thoughts on the mechanism of action of insulin
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- PMID: 1902425
- DOI: 10.2337/diab.40.5.521
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Review
Some thoughts on the mechanism of action of insulin
Diabetes.
1991 May.
Abstract
Proposed mechanisms by which insulin exerts its effects are discussed. Evidence for a role for the tyrosine kinase activity of the insulin receptor and of a phosphorylation/dephosphorylation cascade is presented. The possible roles of phospholipid breakdown, diacylglycerol, and protein kinase C are discussed. The hypothesis that insulin elicits the hydrolysis of a glycosyl phosphatidylinositol to form a mediator of certain of its actions is considered in detail. The evidence that a G protein is involved in insulin action is analyzed.
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