Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Feb;10(1):47-55.
doi: 10.1007/BF00151246.

Pharmacokinetics of 11C-labelled BCNU and SarCNU in gliomas studied by PET

S Mitsuki  1 , M Diksic, T Conway, Y L Yamamoto, J G Villemure, W Feindel
Affiliations

Pharmacokinetics of 11C-labelled BCNU and SarCNU in gliomas studied by PET

S Mitsuki et al. J Neurooncol. 1991 Feb.

Abstract

This paper describes the study of the pharmacodynamics of two 11C-labelled nitrosoureas, 1,3-bis-(2-chloroethyl) nitrosourea (BNCU) and sarcosinamide chloroethylnitrosourea (SarCNU), both labelled in the carbonyl position. Distribution of the radioactivity as measured by positron emission tomography was compared to the distribution of radioactivity observed after injection of 68Ga-EDTA, this being used as an indicator of the blood-brain barrier integrity around the brain tumor. Data suggest that the new nitrosourea, SarCNU, most likely enters brain tissue by different mechanism(s) than BCNU, which enters by diffusion. Data also indicate that use of SarCNU may result in a better tumor to brain ratio than BCNU.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cancer. 1981 Feb 15;47(4):653-7 - PubMed
    1. J Neurooncol. 1985;3(3):229-35 - PubMed
    1. N Engl J Med. 1980 Dec 4;303(23):1323-9 - PubMed
    1. Cancer Treat Rep. 1983 Feb;67(2):121-32 - PubMed
    1. J Comput Assist Tomogr. 1977 Jan;1(1):43-56 - PubMed

Publication types

MeSH terms

LinkOut - more resources