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Review
. 2009 Jan;290(2):121-8.
doi: 10.1111/j.1574-6968.2008.01418.x. Epub 2008 Jan 11.

The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors

Cristal Huysamen  1 , Gordon D Brown
Affiliations
Review

The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors

Cristal Huysamen et al. FEMS Microbiol Lett. 2009 Jan.

Abstract

The mammalian natural killer gene complex (NKC) contains several families of type II transmembrane C-type lectin-like receptors (CLRs) that are best known for their involvement in the detection of virally infected or transformed cells, through the recognition of endogenous (or self) proteinacious ligands. However, certain CLR families within the NKC, particularly those expressed by myeloid cells, recognize structurally diverse ligands and perform a variety of other immune and homoeostatic functions. One such family is the 'Dectin-1 cluster' of CLRs, which includes MICL, CLEC-2, CLEC12B, CLEC9A, CLEC-1, Dectin-1 and LOX-1. Here, we review each of these CLRs, exploring our current understanding of their ligands and functions and highlighting where they have provided new insights into the underlying mechanisms of immunity and homeostasis.

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Figures

Fig. 2
Fig. 2
Cartoon representation of the typical structure of group V CLRs. Dectin-1 and MICL are shown as representatives of activation and inhibitory receptors that are found in this cluster. Proximal signaling components are also indicated. Lollipop structures indicate sites of N-linked glycosylation.
Fig. 1
Fig. 1
Cartoon representation of the genomic organization of the ‘Dectin-1 cluster’ in the NKC on human chromosome 12. Activation receptors are shown in light grey, inhibitory receptors in dark grey, and those whose function is unclear are shown in white.
See this image and copyright information in PMC

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