Gleaning multicomponent T1 and T2 information from steady-state imaging data
- PMID: 19025904
- DOI: 10.1002/mrm.21704
Gleaning multicomponent T1 and T2 information from steady-state imaging data
Abstract
The driven-equilibrium single-pulse observation of T(1) (DESPOT1) and T(2) (DESPOT2) are rapid, accurate, and precise methods for voxelwise determination of the longitudinal and transverse relaxation times. A limitation of the methods, however, is the inherent assumption of single-component relaxation. In a variety of biological tissues, in particular human white matter (WM) and gray matter (GM), the relaxation has been shown to be more completely characterized by a summation of two or more relaxation components, or species, each believed to be associated with unique microanatomical domains or water pools. Unfortunately, characterization of these components on a voxelwise, whole-brain basis has traditionally been hindered by impractical acquisition times. In this work we extend the conventional DESPOT1 and DESPOT2 approaches to include multicomponent relaxation analysis. Following numerical analysis of the new technique, renamed multicomponent driven equilibrium single pulse observation of T(1)/T(2) (mcDESPOT), whole-brain multicomponent T(1) and T(2) quantification is demonstrated in vivo with clinically realistic times of between 16 and 30 min. Results obtained from four healthy individuals and two primary progressive multiple sclerosis (MS) patients demonstrate the future potential of the approach for identifying and assessing tissue changes associated with several neurodegenerative conditions, in particular those associated with WM.
(c) 2008 Wiley-Liss, Inc.
Similar articles
-
Correction of main and transmit magnetic field (B0 and B1) inhomogeneity effects in multicomponent-driven equilibrium single-pulse observation of T1 and T2.Magn Reson Med. 2011 Apr;65(4):1021-35. doi: 10.1002/mrm.22685. Epub 2010 Dec 8. Magn Reson Med. 2011. PMID: 21413066 Free PMC article.
-
Rapid simultaneous high-resolution mapping of myelin water fraction and relaxation times in human brain using BMC-mcDESPOT.Neuroimage. 2017 Feb 15;147:800-811. doi: 10.1016/j.neuroimage.2016.09.064. Epub 2016 Oct 8. Neuroimage. 2017. PMID: 27729276 Free PMC article.
-
Clustering of atlas-defined cortical regions based on relaxation times and proton density.Neuroimage. 2009 Aug 15;47(2):523-32. doi: 10.1016/j.neuroimage.2009.04.079. Epub 2009 May 6. Neuroimage. 2009. PMID: 19426811
-
State of the art survey on MRI brain tumor segmentation.Magn Reson Imaging. 2013 Oct;31(8):1426-38. doi: 10.1016/j.mri.2013.05.002. Epub 2013 Jun 20. Magn Reson Imaging. 2013. PMID: 23790354 Review.
-
Multispectral quantitative magnetic resonance imaging of brain iron stores: a theoretical perspective.Top Magn Reson Imaging. 2006 Feb;17(1):19-30. doi: 10.1097/01.rmr.0000245460.82782.69. Top Magn Reson Imaging. 2006. PMID: 17179894 Review.
Cited by
-
Articular Cartilage of the Human Knee Joint: In Vivo Multicomponent T2 Analysis at 3.0 T.Radiology. 2015 Nov;277(2):477-88. doi: 10.1148/radiol.2015142201. Epub 2015 May 25. Radiology. 2015. PMID: 26024307 Free PMC article.
-
American Society of Biomechanics Clinical Biomechanics Award 2015: MRI assessments of cartilage mechanics, morphology and composition following reconstruction of the anterior cruciate ligament.Clin Biomech (Bristol). 2016 May;34:38-44. doi: 10.1016/j.clinbiomech.2016.03.007. Epub 2016 Mar 31. Clin Biomech (Bristol). 2016. PMID: 27061359 Free PMC article.
-
Assessment of the myelin water fraction in rodent spinal cord using T2-prepared ultrashort echo time MRI.MAGMA. 2016 Dec;29(6):875-884. doi: 10.1007/s10334-016-0579-7. Epub 2016 Jul 9. MAGMA. 2016. PMID: 27394911
-
Black Line Sign in Focal Cortical Dysplasia IIB: A 7T MRI and Electroclinicopathologic Study.Neurology. 2022 Aug 9;99(6):e616-e626. doi: 10.1212/WNL.0000000000200702. Epub 2022 May 16. Neurology. 2022. PMID: 35940890 Free PMC article.
-
Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damage.Neuroimage Clin. 2019;23:101826. doi: 10.1016/j.nicl.2019.101826. Epub 2019 Apr 16. Neuroimage Clin. 2019. PMID: 31026624 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical