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. 2009 Mar;104(3):206-8.
doi: 10.1016/j.ijgo.2008.10.010. Epub 2008 Nov 22.

Outcomes of pregnancies affected by hemoglobin H disease

Theera Tongsong  1 , Kasemsri Srisupundit, Suchaya Luewan
Affiliations

Outcomes of pregnancies affected by hemoglobin H disease

Theera Tongsong et al. Int J Gynaecol Obstet. 2009 Mar.

Abstract

Objective: To determine the outcomes of pregnancies affected by hemoglobin H (HbH) disease.

Methods: A retrospective cohort study was conducted with 120 women with singleton pregnancies complicated by HbH disease only. The controls-to-cases ratio was 2:1.

Results: Maternal outcomes were similar in the 2 groups. The incidences of fetal growth restriction (relative risk [RR], 2.4; 95% confidence interval [CI], 1.60-3.50), preterm birth (RR, 1.4; 95% CI, 1.03-1.96), and low birth weight (RR, 1.9; 95% CI, 1.46-2.56) were significantly higher in the study than in the control group. The perinatal mortality rate was slightly higher in the study group.

Conclusion: In spite of attempts to keep hemoglobin levels sufficiently high (>7.0 g/dL), pregnancies with HbH disease were significantly associated with increased risks of fetal growth restriction, preterm birth, and low birth weight.

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