Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Dec;27(12):975-8.
doi: 10.1016/j.annfar.2008.10.005. Epub 2008 Nov 22.

Interest of BIS monitoring to guide propofol infusion during the anhepatic phase of orthotopic liver transplantation

L Tremelot  1 , A Restoux, C Paugam-Burtz, S Dahmani, L Massias, C Peuch, J Belghiti, J Mantz
Affiliations

Interest of BIS monitoring to guide propofol infusion during the anhepatic phase of orthotopic liver transplantation

L Tremelot et al. Ann Fr Anesth Reanim. 2008 Dec.

Abstract

Objective: The anhepatic phase of orthotopic liver transplantation (OLT) is associated with significant changes in pharmacokinetics. The aim of this study was to compare the influence of this phase on propofol target concentrations during BIS guided target controlled infusion (TCI).

Study design: Prospective study.

Patients and methods: Eight patients aged 25 to 65 years, Child-Pugh status A-B scheduled for OLT were prospectively included. Anesthesia was performed using TCI of propofol (Diprifusor, Marsh pharmacokinetic model), sufentanil and cisatracurium. Propofol target concentration was adjusted to maintain BIS values between 40 and 50.

Results: To maintain stable BIS values, propofol target concentrations should be decreased during the anhepatic phase versus the dissection one (2.0 microg/ml+/-0.8 versus 3.0 microg/ml+/-0.9, p<0.0001).

Conclusion: BIS could be useful to titrate propofol infusion during the anhepatic phase of OLT.

PubMed Disclaimer

Comment in

LinkOut - more resources