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. 2009 Jan;94(1):141-4.
doi: 10.3324/haematol.13224. Epub 2008 Nov 23.

Characterization of 35 new cases with four different MPLW515 mutations and essential thrombocytosis or primary myelofibrosis

Susanne Schnittger, Ulrike Bacher, Claudia Haferlach, Dietrich Beelen, Peter Bojko, Dieter Bürkle, Robert Dengler, Andrea Distelrath, Michael Eckart, Robert Eckert, Stefan Fries, Jan Knoblich, Georg Köchling, Hans-Peter Laubenstein, Petro Petrides, Manfred Planker, Rudolf Pihusch, Rudolf Weide, Wolfgang Kern, Torsten Haferlach

Characterization of 35 new cases with four different MPLW515 mutations and essential thrombocytosis or primary myelofibrosis

Susanne Schnittger et al. Haematologica. 2009 Jan.
No abstract available

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Figures

Figure 1.
Figure 1.
(A) The novel MPLW515A mutation in case 1. This case revealed an approximately 0.2 mutation to wild type (wt) level. On the left the melting curve assay that detects the mutation. On the right further characterization by sequencing compared to a wt allele. (B) The novel MPLW515R mutation in case 28. On the left the melting curve assay that detects the mutation. On the right further characterization by sequencing compared to a wt allele. In addition to the W515R mutation this case has a silent mutation at AA position R515 due to g>a exchange.
See this image and copyright information in PMC

References

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    1. Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006;3:e270. - PMC - PubMed
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    1. Schnittger S, Bacher U, Haferlach C, Dengler R, Krober A, Kern W, et al. Detection of an MPLW515 mutation in a case with features of both essential thrombocythemia and refractory anemia with ringed sideroblasts and thrombocytosis. Leukemia. 2007;22:453–555. - PubMed
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