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Multicenter Study
. 2008 Nov 14;14(42):6531-5.
doi: 10.3748/wjg.14.6531.

Colorectal carcinoma in Lagos and Sagamu, Southwest Nigeria: a histopathological review

Fatimah-Biade Abdulkareem  1 , Emmanuel-Kunle Abudu, Nicholas-Awodele Awolola, Stephen-Olafimihan Elesha, Olorunda Rotimi, Olakanmi-Raphael Akinde, Ayoola-Oluwole Atoyebi, Adedoyin-Adekunle Adesanya, Adetola-Olubunmi Daramola, Adekumbiola-Aina-Fehintola Banjo, Charles-Chidozie Anunobi
Affiliations
Multicenter Study

Colorectal carcinoma in Lagos and Sagamu, Southwest Nigeria: a histopathological review

Fatimah-Biade Abdulkareem et al. World J Gastroenterol. .

Abstract

Aim: To study the frequency, gender and age distribution as well as pathological characteristics of colorectal carcinoma (CRC) in Lagos and Sagamu in SW Nigeria.

Methods: This is a retrospective pathological review of histologically diagnosed CRC from 5 laboratories in Lagos and Sagamu. The clinical data, such as age, sex and clinical summary were extracted from demographic information. Cases of anal cancer were excluded from this study.

Results: There were 420 cases (237 males and 183 females) of CRC. It peaked in the 60-69 year age group (mean: 50.7; SD: 16.2), M:F ratio 1.3:1 and 23% occurred below 40 years. The majority was well to moderately differentiated adenocarcinoma 321 (76.4%), mucinous carcinoma 45 (10.7%) and signet ring carcinoma 5 (1.2%), and more common in patients under 40 years compared to well differentiated tumors. The recto-sigmoid colon was the most common site (58.6%). About 51% and 34% of cases presented at TNM stages II and III, respectively.

Conclusion: CRC is the commonest malignant gastrointestinal (GIT) tumor most commonly located in the recto-sigmoid region. The age and sex prevalence and histopathological features concur with reports from other parts of the world.

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