Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2009 Feb;48(1):1-5.
doi: 10.1007/s00394-008-0758-z. Epub 2008 Nov 21.

The effect of marine n-3 fatty acids in different doses on plasma concentrations of Lp-PLA2 in healthy adults

Maria Weinkouff Pedersen  1 , Wolfgang Koenig, Jeppe Hagstrup Christensen, Erik Berg Schmidt
Affiliations
Randomized Controlled Trial

The effect of marine n-3 fatty acids in different doses on plasma concentrations of Lp-PLA2 in healthy adults

Maria Weinkouff Pedersen et al. Eur J Nutr. 2009 Feb.

Abstract

Background: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging independent risk factor for cardiovascular disease (CVD). Lp-PLA(2) can be modified by lipid lowering drugs, but it is unknown whether diet can reduce plasma levels of Lp-PLA(2).

Aim of the study: The aim of the trial was to study the effect of marine n-3 polyunsaturated fatty acids (PUFA) on plasma Lp-PLA(2) levels in healthy subjects.

Methods: Sixty healthy subjects were randomized to a moderate dose (2 g) of n-3 PUFA, a high dose (6.6 g) of n-3 PUFA or olive oil (control) daily for 12 weeks. Plasma Lp-PLA(2) was measured at baseline and after the interventions.

Results: Plasma Lp-PLA(2) levels were unchanged in all three groups before and after the supplements. Neither did the results differ between groups. There was no correlation between the content of n-3 PUFA in platelets or granulocytes or plasma Lp-PLA(2).

Conclusion: Marine n-3 PUFA had no effect on plasma levels of Lp-PLA(2) in healthy adults and relatively young people.

PubMed Disclaimer

References

    1. Atherosclerosis. 2008 Jan;196(1):420-424 - PubMed
    1. Curr Opin Lipidol. 2003 Aug;14(4):347-52 - PubMed
    1. Eur Heart J. 2007 Mar;28(6):699-704 - PubMed
    1. N Engl J Med. 2000 Oct 19;343(16):1148-55 - PubMed
    1. Circulation. 2004 Oct 5;110(14):1903-8 - PubMed

Publication types

LinkOut - more resources