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. 2009 Jan;26(1):7-11.
doi: 10.1007/s10815-008-9273-7. Epub 2008 Nov 22.

Intrauterine insemination with husband semen: an evaluation of pregnancy rate and factors affecting outcome

Shahrzad Zadehmodarres  1 , Belgheis Oladi, Shahrbanoo Saeedi, Fatemeh Jahed, Haleh Ashraf
Affiliations

Intrauterine insemination with husband semen: an evaluation of pregnancy rate and factors affecting outcome

Shahrzad Zadehmodarres et al. J Assist Reprod Genet. 2009 Jan.

Abstract

Purpose: The aim was to determine pregnancy rate following intrauterine insemination (IUI) and its associated factors in a university assisted reproductive technique center in Tehran, Iran.

Methods: A retrospective analysis of 350 IUI cycles with ovarian stimulation by clomiphene citrate and/or gonadotropins was performed.

Results: The overall pregnancy rate was 22% (77/350). Of the 77 pregnancies, 88.3% resulted in live birth, 7.8% in spontaneous abortion, 2.6% in blighted ovum and 1.3% were ectopic. Logistic regression analysis revealed three predictive variables as regards pregnancy: number of the treatment cycle (OR:3.5 CI:1.9 - 6.4 p:0.006), duration of infertility (OR:2.1 CI:1.2 - 3.7 p = 0.001) and age (OR:2.15 CI:1.1 - 4.4 p = 0.04). Pregnancy rate did not have any independent relation to sperm count, type of infertility, number and size of follicle and side of ovulatory ovary.

Conclusion: Our results indicate that clomiphene citrate and/or gonadotropins IUI is a convenient and useful treatment option in women with younger age ( <30 years) and fewer treatment cycles and fewer infertility duration (4 years).

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