doi: 10.1038/351122a0.
Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain
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- PMID: 1903181
- DOI: 10.1038/351122a0
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Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain
Nature.
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Abstract
Ha-Ras augments c-Jun-mediated transactivation by potentiating the activity of the c-Jun activation domain. Ha-Ras also causes a corresponding increase in phosphorylation of specific sites in that part of the c-Jun protein. A Ha-Ras-induced protein kinase cascade resulting in hyperphosphorylation of the c-Jun activation domain could explain how these oncoproteins cooperate to transform rat embryo fibroblasts.
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