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Comment
. 2008 Dec 2;105(48):18647-8.
doi: 10.1073/pnas.0810508106. Epub 2008 Nov 24.

How influenza virus is locked out of the cell

Yorgo Modis  1
Affiliations
Comment

How influenza virus is locked out of the cell

Yorgo Modis. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The structural basis of the inactivation of the influenza virus HA envelope protein by TBHQ. (A) TBHQ (shown schematically in magenta) binds in a hydrophobic pocket near the C terminus of the short α-helix, at the interface between monomers in the prefusion HA trimer. For clarity, only the core regions of HA2 are shown. In group 1 influenza subtypes, the TBHQ binding site is absent, explaining the failure of TBHQ to inhibit membrane fusion of group 1 viruses. (B) TBHQ stabilizes the prefusion trimer, thereby inhibiting the conformational rearrangements that are required for membrane fusion and viral entry.
See this image and copyright information in PMC

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