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Comment
. 2008 Dec;57(12):3184-6.
doi: 10.2337/db08-1275.

Immunopathogenic interaction of environmental triggers and genetic susceptibility in diabetes: is epigenetics the missing link?

Sally A Litherland  1
Affiliations
Comment

Immunopathogenic interaction of environmental triggers and genetic susceptibility in diabetes: is epigenetics the missing link?

Sally A Litherland. Diabetes. 2008 Dec.
No abstract available

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Figures

FIG. 1.
FIG. 1.
A vicious cycle: interactions of environmental triggers stimulate genetic regulation, which in turn promotes a proinflammatory microenvironment and immune dysfunction. Epigenetic regulation of genes in a chromosomal region through their nontranscribed regulatory sequences both affects and is affected by environmental and genetic variations that confer susceptibility to disease. This sets the stage for interactions that self-perpetuate and feedback to exacerbate immunopathology and suggests a central role for epigenetic mechanisms in the etiology of autoimmune diabetes.
See this image and copyright information in PMC

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