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Review
. 2008 Dec;31(12):2391-7.
doi: 10.2337/dc08-1034.

Diabetes and risk of Non-Hodgkin's lymphoma: a meta-analysis of observational studies

Joanna Mitri  1 , Jorge Castillo, Anastassios G Pittas
Affiliations
Review

Diabetes and risk of Non-Hodgkin's lymphoma: a meta-analysis of observational studies

Joanna Mitri et al. Diabetes Care. 2008 Dec.

Abstract

Objective: To examine the epidemiologic association between diabetes and risk of non-Hodgkin's lymphoma (NHL).

Research design and methods: We searched MEDLINE for observational studies on the association between diabetes and NHL in adults using the keywords "diabetes" and "lymphoma." Prospective cohort studies that reported relative risks or standardized incidence ratios and case-control studies that reported odds ratios with 95% CIs were included. A random-effects model was used to combine results from the individual studies.

Results: A total of 15 manuscripts (reporting data from 5 prospective cohort and 11 case-control studies) met the inclusion criteria. Combining data from all studies, the risk ratio (RR) of developing NHL in patients with diabetes was 1.19 (95% CI 1.04-1.35). Based on prospective studies, patients with diabetes had an RR of developing NHL of 1.41 (1.07-1.88), without heterogeneity among studies (I(2) = 34.3%; P > 0.10). Based on case-control studies, patients with diabetes had an RR of 1.12 (95% CI 0.95-1.31) of developing NHL compared with people without diabetes, with some heterogeneity among studies (I(2) = 36.28%; P = 0.09).

Conclusions: Diabetes is associated with a moderately increased risk of NHL, which is consistent with other reported associations between diabetes and malignancies. Future studies should focus on elucidating potential pathophysiologic links between diabetes and NHL.

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Figures

Figure 1
Figure 1
Search results.
Figure 2
Figure 2
Risk estimates of developing NHL for patients with diabetes compared with control subjects (patients without diabetes).
See this image and copyright information in PMC

References

    1. Chiu BC, Weisenburger DD: An update of the epidemiology of non-Hodgkin's lymphoma. Clin Lymphoma 4:161–168, 2003 - PubMed
    1. Winer N, Sowers JR: Epidemiology of diabetes. J Clin Pharmacol 44:397–405, 2004 - PubMed
    1. El-Serag HB, Hampel H, Javadi F: The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence. Clin Gastroenterol Hepatol 4:369–380, 2006 - PubMed
    1. Everhart J, Wright D: Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis. Jama 273:1605–1609, 1995 - PubMed
    1. Hjalgrim H, Frisch M, Ekbom A, Kyvik KO, Melbye M, Green A: Cancer and diabetes: a follow-up study of two population-based cohorts of diabetic patients. J Intern Med 241:471–475, 1997 - PubMed

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