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Comment
. 2008 Nov 25;18(22):R1061-4.
doi: 10.1016/j.cub.2008.09.023.

Anion channels: regulation of ClC-3 by an orphan second messenger

Alexi K Alekov  1 , Christoph Fahlke
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Anion channels: regulation of ClC-3 by an orphan second messenger

Alexi K Alekov et al. Curr Biol. .
Free article

Abstract

ClC-3 is a ubiquitously expressed chloride channel isoform whose biological function has been a matter of debate for many years. A recent study reporting its regulation by Ins(3,4,5,6)P(4) assigns novel transport functions and cellular roles to ClC-3 and identifies a regulatory pathway that affects epithelial transport and endosomal pH regulation.

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