Immunologic pathogenesis of multiple sclerosis

doi:10.1007/s12264-008-2429-8

Review

. 2008 Dec;24(6):381-6.

doi: 10.1007/s12264-008-2429-8.

Immunologic pathogenesis of multiple sclerosis

Min-Fang Guo¹, Ning Ji, Cun-Gen Ma

Affiliations

PMID: 19037324
PMCID: PMC5552594
DOI: 10.1007/s12264-008-2429-8

Review

Immunologic pathogenesis of multiple sclerosis

Min-Fang Guo et al. Neurosci Bull. 2008 Dec.

. 2008 Dec;24(6):381-6.

doi: 10.1007/s12264-008-2429-8.

Authors

Min-Fang Guo¹, Ning Ji, Cun-Gen Ma

Affiliation

¹ Institute of Brain Science, Shanxi Datong University, Datong, China.

PMID: 19037324
PMCID: PMC5552594
DOI: 10.1007/s12264-008-2429-8

Abstract
in English, Chinese

Multiple sclerosis (MS) is an autoimmune disease. The etiology and pathogenesis of MS remain unclear. At present, there are substantial evidences to support the hypothesis that genetics plays a crucial role. The people who have genetic predisposing genes easily develop immune-mediated disorder, probably in conjunction with environmental factors. The aim of this review is to describe recent observations regarding the immunologic pathogenesis of MS.

多发性硬化是一种自身免疫性疾病, 其发病机制至今还未阐明, 目前认为可能是一些携有先天遗传易感基因的个体有易发生免疫调节功能紊乱的趋势, 在后天环境中外因的作用下, 诱发对中枢髓鞘成分的异常自身免疫应答而致病。本文综述了近年来的相关文献和科研成果, 旨在探讨多发性硬化的免疫学发病机制。

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References

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1. Huseby E.S., Liggitt D., Brabb T., Schnabel B., Ohlén C., Goverman J. A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J Exp Med. 2001;194:669–676. doi: 10.1084/jem.194.5.669. - DOI - PMC - PubMed
1. Crawford M.P., Yan S.X., Ortega S.B., Mehta R.S., Hewitt R.E., Price D.A., et al. High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay. Blood. 2004;103:4222–4231. doi: 10.1182/blood-2003-11-4025. - DOI - PubMed
1. Link H. The cytokine storm in multiple sclerosis. Mult Scler. 1998;4:12–15. doi: 10.1191/135245898678909141. - DOI - PubMed
1. Trinchieri G., Pflanz S., Kastelein R.A. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity. 2003;19:641–644. doi: 10.1016/S1074-7613(03)00296-6. - DOI - PubMed

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[1] Ando D.G., Clayton J., Kono D., Urban J.L., Sercarz E.E. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell Immunol. 1989;124:132–143. doi: 10.1016/0008-8749(89)90117-2. - DOI - PubMed

[2] Ando D.G., Clayton J., Kono D., Urban J.L., Sercarz E.E. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell Immunol. 1989;124:132–143. doi: 10.1016/0008-8749(89)90117-2. - DOI - PubMed

[3] Huseby E.S., Liggitt D., Brabb T., Schnabel B., Ohlén C., Goverman J. A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J Exp Med. 2001;194:669–676. doi: 10.1084/jem.194.5.669. - DOI - PMC - PubMed

[4] Huseby E.S., Liggitt D., Brabb T., Schnabel B., Ohlén C., Goverman J. A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J Exp Med. 2001;194:669–676. doi: 10.1084/jem.194.5.669. - DOI - PMC - PubMed

[5] Crawford M.P., Yan S.X., Ortega S.B., Mehta R.S., Hewitt R.E., Price D.A., et al. High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay. Blood. 2004;103:4222–4231. doi: 10.1182/blood-2003-11-4025. - DOI - PubMed

[6] Crawford M.P., Yan S.X., Ortega S.B., Mehta R.S., Hewitt R.E., Price D.A., et al. High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay. Blood. 2004;103:4222–4231. doi: 10.1182/blood-2003-11-4025. - DOI - PubMed

[7] Link H. The cytokine storm in multiple sclerosis. Mult Scler. 1998;4:12–15. doi: 10.1191/135245898678909141. - DOI - PubMed

[8] Link H. The cytokine storm in multiple sclerosis. Mult Scler. 1998;4:12–15. doi: 10.1191/135245898678909141. - DOI - PubMed

[9] Trinchieri G., Pflanz S., Kastelein R.A. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity. 2003;19:641–644. doi: 10.1016/S1074-7613(03)00296-6. - DOI - PubMed

[10] Trinchieri G., Pflanz S., Kastelein R.A. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity. 2003;19:641–644. doi: 10.1016/S1074-7613(03)00296-6. - DOI - PubMed

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Immunologic pathogenesis of multiple sclerosis

Affiliation

Immunologic pathogenesis of multiple sclerosis

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Abstract
in English, Chinese

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Abstract in English, Chinese

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