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Review
. 2009 Jan;217(2):299-306.
doi: 10.1002/path.2478.

Prostate cancer stem cells

S H Lang  1 , F M Frame, A T Collins
Affiliations
Review

Prostate cancer stem cells

S H Lang et al. J Pathol. 2009 Jan.

Abstract

Despite the discovery over 60 years ago by Huggins and Hodges that prostate cancers respond to androgen deprivation therapy, hormone-refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell-like cells coexisting within a heterogeneous tumour mass that drive tumour formation, maintain tumour homeostasis and initiate metastases. This review focuses upon current evidence for prostate cancer stem cells, addressing the identification and properties of both normal and transformed prostate stem cells.

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Figures

Figure 1
Figure 1
A frozen section of prostate labelled with α2-integrin antibody, directly labelled with fluorescein isothiocyanate (FITC) and viewed by confocal microscopy. Reproduced with permission from
Figure 2
Figure 2
A colony derived from a single PKH26-labelled prostate epithelial cell at day 4. As the cells divide, the intensity of fluorescence is diluted. Note the quiescent, bright cells at the edge of the colony
See this image and copyright information in PMC

References

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