Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009;48(1):154-6.
doi: 10.1002/anie.200804888.

Catalytic asymmetric cross-couplings of racemic alpha-bromoketones with arylzinc reagents

Pamela M Lundin  1 , Jorge Esquivias, Gregory C Fu
Affiliations

Catalytic asymmetric cross-couplings of racemic alpha-bromoketones with arylzinc reagents

Pamela M Lundin et al. Angew Chem Int Ed Engl. 2009.
No abstract available

PubMed Disclaimer

References

    1. For some leading references, see: Fox JM, Huang X, Chieffi A, Buchwald SL. J Am Chem Soc. 2000;122:1360–1370.

    1. For overviews, see: a) Reference 1; Culkin DA, Hartwig JF. Acc Chem Res. 2003;36:234–245.

    1. For key studies, as well as references to the synthesis and utility of enantioenriched α-arylketones, see: Ahman J, Wolfe JP, Troutman MV, Palucki M, Buchwald SL. J Am Chem Soc. 1998;120:1918–1919.Hamada T, Chieffi A, Ahman J, Buchwald SL. J Am Chem Soc. 2002;124:1261–1268.Liao X, Weng Z, Hartwig JF. J Am Chem Soc. 2008;130:195–200.

    1. For a nickel-catalyzed process, see: Chen G, Kwong FY, Chan HO, Yu WY, Chan ASC. Chem Commun. 2006:1413–1415.

    1. pKa (acetone): 26.5; pKa (PhCH2COCH3): 19.8 (values in DMSO taken from: Bordwell FG, Zhang S, Zhang XM, Liu WZ. J Am Chem Soc. 1995;777:7092–7096.

Publication types

LinkOut - more resources