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. 2008 Nov 29;1(1):362.
doi: 10.1186/1757-1626-1-362.

Preoperative detection of insulinomas: two case reports

Mesut Ozkaya  1 , Mehmet Fatih Yuzbasioglu, Irfan Koruk, Erman Cakal, Mustafa Sahin, Basak Cakal
Affiliations

Preoperative detection of insulinomas: two case reports

Mesut Ozkaya et al. Cases J. .

Abstract

Background: Insulinoma is the most common endocrine tumor of the pancreas. Accurate preoperative detection and localization of insulinomas is essential for the appropriate selection of candidates for surgery. We present two cases with benign pancreatic insulinoma.

Case presentation: Preoperative evaluation for patients with suspected insulinomas has been controversial. Endoscopic ultrasonography (EUS) has a sensitivity of 95% in well skilled operators and well tolerated preoperative imaging method.

Conclusion: We have detected the insulinomas with EUS before surgery in our patients but other imaging modalities did not help us for localization of them. Patients have been asymptomatic postoperatively with no hypoglycemia on repeat fasting. We reviewed here the different modalities for preoperative localization of insulinoma.

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Figures

Figure 1
Figure 1
In the EUS scanning at the pancreas uncinate process, hypoechoic 13 mm nodular lesion.
Figure 2
Figure 2
In the EUS scanning at the pancreas uncinate process, hypoechoic 11 mm nodular lesion.
See this image and copyright information in PMC

References

    1. Service FJ, Mc Mahom MM. Functioning insülinoma-insidence recurrence and long term survival of patient: a 60 year study. Mayo Clin Proc. 1991;66:771–719. - PubMed
    1. Brentjens R, Saltz L. Islet cell tumors of the pancreas. Surg Clin Nort America. 2001;82:527–542. doi: 10.1016/S0039-6109(05)70141-9. - DOI - PubMed
    1. Karam MD, Masharani U. Hypoglycemic disorders. In: Greenspan FS, Gardner DG, editor. Basic and Clinical Endocrinology. 7. New York, McGraw-Hill Companies; 2004. pp. 747–766.
    1. Arýoðlu E, Gottlieb N, Koch C, et al. Natural History of a proinsülin secreting insulinoma: from symptomatic hypoglycemia to clinical diabetes. J Clin Endocrin Metab. 2000;85:3628–31. doi: 10.1210/jc.85.10.3628. - DOI - PubMed
    1. Virally ML, Guillausseau PJ. Hypoglycemia in adults. Diabetes and Metab. 1999;25:477–490. - PubMed

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