Comment
doi: 10.1016/j.cell.2008.11.007.
When the gut talks to bone
Affiliations
- PMID: 19041744
- DOI: 10.1016/j.cell.2008.11.007
Item in Clipboard
Comment
When the gut talks to bone
Cell.
.
Free article
Abstract
Mutations in LRP5, a coreceptor for Wnt proteins, cause the disease osteoporosis pseudoglioma. A new study by Yadav et al. (2008) now challenges the view that LRP5 controls bone mass through Wnt signaling in bone and argues instead that LRP5 regulates bone mass indirectly through its effects on serotonin synthesis in the gut.
Comment on
-
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum.Cell. 2008 Nov 28;135(5):825-37. doi: 10.1016/j.cell.2008.09.059. Cell. 2008. PMID: 19041748 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
