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Comment
. 2008 Dec;8(6):451-3.
doi: 10.1016/j.cmet.2008.11.006.

A cholesterol toggle switch

Randolph Y Hampton  1
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Free article
Comment

A cholesterol toggle switch

Randolph Y Hampton. Cell Metab. 2008 Dec.
Free article

Abstract

Cholesterol levels in mammalian cells are controlled by an intricate mechanism in which the transcription factor SREBP plays a key role. Work in this issue (Radhakrishnan et al., 2008) employing direct measurement of endoplasmic reticulum cholesterol levels offers insights into the "switch" that controls this system with surprising precision.

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