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Review
. 2008 Dec;22(6):955-69.
doi: 10.1016/j.beem.2008.09.017.

Molecular pathology of thyroid cancer: diagnostic and clinical implications

James A Fagin  1 , Nicholas Mitsiades
Affiliations
Review

Molecular pathology of thyroid cancer: diagnostic and clinical implications

James A Fagin et al. Best Pract Res Clin Endocrinol Metab. 2008 Dec.

Abstract

There is now a reasonably good understanding of the key oncogenic events involved in the initiation and progression of thyroid cancer. Many of these are characteristic of certain tumor types, and their presence conveys diagnostic and prognostic information. It is not yet clear how this information will be applied to clinical practice. Based on preclinical evidence, mutations of genes encoding certain kinases may also predict response to specific tyrosine kinase inhibitors, although this has not yet been explored systematically in clinical trials.

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Conflict of interest statement

CONFLICT OF INTEREST STATEMENT

The authors have no conflicts of interest to declare.

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