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Review
. 2008 Dec;18(12):1707-12.

[Optimization of signaling pathways for bone regeneration]

[Article in Japanese]
Naoshi Ogata  1 , Ung-il Chung, Yuichi Tei, Shinsuke Ohba, Hiroshi Kawaguchi
Affiliations
  • PMID: 19043183
Review

[Optimization of signaling pathways for bone regeneration]

[Article in Japanese]
Naoshi Ogata et al. Clin Calcium. 2008 Dec.

Abstract

We have developed an ES cell-based monitoring system for osteogenic differentiation and identified a potent combination of osteogenic genes. ES cells were isolated from mice carrying a transgene expressing GFP driven by the 2.3 kb fragment of rat type I collagen alpha1 promoter. We have screened cDNA libraries and combinations of major osteogenesis-related genes and identified that the combination of constitutively active activin receptor-like kinase 6 (caALK6) and runt-related transcription factor 2 (Runx2) was the minimal unit that induced GFP. These combinations of genes would be a potent and ideal tool for bone regeneration.

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