doi: 10.1038/351456a0.
New use of BCG for recombinant vaccines
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- PMID: 1904554
- DOI: 10.1038/351456a0
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New use of BCG for recombinant vaccines
Nature.
.
Abstract
BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.
Comment in
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BCG. Rebirth of a star performer.Nature. 1991 Jun 6;351(6326):442-3. doi: 10.1038/351442d0. Nature. 1991. PMID: 2046745 No abstract available.
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