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. 1991 Jun 6;351(6326):456-60.
doi: 10.1038/351456a0.

New use of BCG for recombinant vaccines

C K Stover  1 , V F de la Cruz, T R Fuerst, J E Burlein, L A Benson, L T Bennett, G P Bansal, J F Young, M H Lee, G F Hatfull, et al.
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New use of BCG for recombinant vaccines

C K Stover et al. Nature. .

Abstract

BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.

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