Comment
doi: 10.1016/j.cmet.2008.10.007.
Raptor swoops in on metabolism
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- PMID: 19046565
- DOI: 10.1016/j.cmet.2008.10.007
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Comment
Raptor swoops in on metabolism
Cell Metab.
2008 Nov.
Free article
Abstract
The mammalian target of rapamycin (mTOR) serine/threonine kinase plays a central role in insulin signaling and cell growth, through two distinct complexes with its subunits raptor or rictor. In this issue, two reports utilizing tissue-specific knockout mice detail key roles for mTORC1 in skeletal muscle and adipose tissue function.
Comment on
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Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration.Cell Metab. 2008 Nov;8(5):399-410. doi: 10.1016/j.cmet.2008.09.003. Cell Metab. 2008. PMID: 19046571
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Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy.Cell Metab. 2008 Nov;8(5):411-24. doi: 10.1016/j.cmet.2008.10.002. Cell Metab. 2008. PMID: 19046572
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