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. 2009 Feb;87(2):113-9, discussion 120-1.
doi: 10.1038/icb.2008.96. Epub 2008 Dec 2.

On the opposing views of the self-nonself discrimination by the immune system

Melvin Cohn  1
Affiliations

On the opposing views of the self-nonself discrimination by the immune system

Melvin Cohn. Immunol Cell Biol. 2009 Feb.

Abstract

Today's generally accepted view of the self-nonself discrimination was voiced by Miller(1) in 2004 in a thought-provoking essay. In spite of its popularity, this position has its limitations, which are analyzed here with a view toward establishing an interactive discussion that hopefully will culminate in agreed upon decisive experiments. The inadequacies of Miller's view of the self-nonself discrimination and their resolution under the associative recognition of antigen model are analyzed.

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References

    1. Miller J. Self–nonself discrimination by T lymphocytes. CR Biologies. 2004;327:399–408. - PubMed
    1. Miller JFAP, Basten A. Mechanism of tolerance to self. Curr Opin Immunol. 1996;8:815–821. - PubMed
    1. Cohn M. The self–nonself discrimination: reconstructing a cabbage from sauerkraut. Res Immunol. 1992;143:323–334. - PubMed
    1. Cohn M. A biological context for the self–nonself discrimination and the regulation of effector class by the immune system. Immunol Res. 2005;31:133–150. - PubMed
    1. Cohn M. The common sense of the self–nonself discrimination. Springer Semin Immunopathol. 2005;27:3–17. - PubMed

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