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Editorial
. 2008 Sep-Oct;1(2-3):78-82.
doi: 10.1242/dmm.000976.

Mouse xenograft models vs GEM models for human cancer therapeutics

Ann Richmond, Yingjun Su
Editorial

Mouse xenograft models vs GEM models for human cancer therapeutics

Ann Richmond et al. Dis Model Mech. 2008 Sep-Oct.
No abstract available

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Figures

Fig. 1.
Fig. 1.
Types of murine model for studying human cancers.
See this image and copyright information in PMC

References

    1. Baselga J, Norton L, Albanell J, Kim YM, Mendelsohn J. 1998. Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Cancer Res. 58, 2825–2831 - PubMed
    1. Bernard D, Peakman M, Hayday AC. 2008. Establishing humanized mice using stem cells: maximizing the potential. Clin. Exp. Immunol. 152, 406–414 - PMC - PubMed
    1. Davis DW, Inoue K, Dinney CP, Hicklin DJ, Abbruzzese JL, McConkey DJ. 2004. Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts. Cancer Res. 64, 4601–4610 - PubMed
    1. Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, et al. 2004. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350, 2335–2342 - PubMed
    1. Johnson JI, Decker S, Zaharevitz D, Rubinstein LV, Venditti JM, Schepartz S, Kalyandrug S, Christian M, Arbuck S, Hollingshead M, et al. 2001. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br. J. Cancer 84, 1424–1431 - PMC - PubMed

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