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Clinical Trial
. 2009 Apr;92(2):177-83.
doi: 10.1007/s11060-008-9750-y. Epub 2008 Nov 29.

A multimodal strategy based on surgery, radiotherapy, ICE regimen and high dose chemotherapy in atypical teratoid/rhabdoid tumours: a single institution experience

Paola Fidani  1 , Maria Antonietta De Ioris, Annalisa Serra, Luigi De Sio, Ilaria Ilari, Raffaele Cozza, Renata Boldrini, Giuseppe Maria Milano, Maria Luisa Garrè, Alberto Donfrancesco
Affiliations
Clinical Trial

A multimodal strategy based on surgery, radiotherapy, ICE regimen and high dose chemotherapy in atypical teratoid/rhabdoid tumours: a single institution experience

Paola Fidani et al. J Neurooncol. 2009 Apr.

Abstract

Purpose: Atypical Teratoid/Rhabdoid Tumour is a rare and aggressive childhood tumour. The outcome of a series treated with the same multimodal strategy was reported.

Patients: The patients were treated with surgery, 2 courses of ifosfamide/carboplatin/etoposide(ICE), 2 courses of cyclophosphamide/etoposide/carboplatino/thiotepa (CECAT) or 2 other ICE courses, high dose chemotherapy (HDC) and radiotherapy.

Results: Eight patients underwent primary surgery achieving a complete removal in 3. Progressive disease (PD) occurred in 2/8 patients during ICE courses and in 3/4 during CECAT courses. After 4 courses 5 patients presented a PD. HDC was performed in 3 patients followed by local radiotherapy. The Kaplan Meier OS and EFS probability at 5 years are, respectively, 50% (CI 11-80%) and 33% (CI 6-66%).

Conclusion: A strategy based on surgery, including a second surgical look, and on radiotherapy appears the best option. ICE regimen and HDC correlate with good prognosis in some patients but this approach needs further evaluation.

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References

    1. Int J Radiat Oncol Biol Phys. 2006 Mar 15;64(4):1038-43 - PubMed
    1. Am J Surg Pathol. 1998 Sep;22(9):1083-92 - PubMed
    1. J Neurooncol. 2005 Mar;72(1):77-84 - PubMed
    1. Cancer. 2005 Apr 25;105(2):65-70 - PubMed
    1. J Neuropathol Exp Neurol. 2002 Mar;61(3):215-25; discussion 226-9 - PubMed

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