Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jan;342(1):27-33.
doi: 10.1002/ardp.200800181.

New 1H-pyrazole-4-carboxamides with antiplatelet activity

Klaus Rehse  1 , Joscha Kotthaus, Laleh Khadembashi
Affiliations

New 1H-pyrazole-4-carboxamides with antiplatelet activity

Klaus Rehse et al. Arch Pharm (Weinheim). 2009 Jan.

Abstract

Nine title compounds were synthesized and investigated in the Born test for their antiplatelet activities against collagen, ADP, adrenaline, and platelet activating factor (PAF) as inducers of the aggregation. Using collagen three compounds with IC50 values below 100 microM were found (3b, 3e, 3i). Activities in nanomolar concentrations were observed against ADP (3b, IC50 = 9.4 nM), adrenaline (3i, IC50 = 5.8 nM), and platelet activating factor (3e, IC50 = 0.45 nM).

PubMed Disclaimer

MeSH terms

LinkOut - more resources