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. 1991 Feb 1;540(1-2):335-9.
doi: 10.1016/0006-8993(91)90532-z.

Neurobiochemical evidence for calcium-induced depolarization of EGTA-pretreated hippocampal synaptosomes

T W Vickroy  1
Affiliations

Neurobiochemical evidence for calcium-induced depolarization of EGTA-pretreated hippocampal synaptosomes

T W Vickroy. Brain Res. .

Abstract

The neurochemical effects of calcium were determined in hippocampal cholinergic synaptosomes which had been prepared and preincubated in calcium-free medium containing 50 microM EGTA. Calcium (and barium) reversibly stimulated [3H]acetylcholine release and produced a long-lasting elevation of high-affinity [3H]choline uptake. Both effects were blocked by omega-conotoxin and substantially reduced by tetrodotoxin. Together, these data indicate that calcium causes membrane depolarization and is associated with opening of voltage-gated sodium channels in EGTA-pretreated synaptosomes.

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