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. 2009 Feb;19(2):147-51.
doi: 10.1016/j.euroneuro.2008.10.006. Epub 2008 Dec 3.

Psychosis and brain volume changes during the first five years of schizophrenia

W Cahn  1 , M Rais, F P Stigter, N E M van Haren, E Caspers, H E Hulshoff Pol, Z Xu, H G Schnack, R S Kahn
Affiliations

Psychosis and brain volume changes during the first five years of schizophrenia

W Cahn et al. Eur Neuropsychopharmacol. 2009 Feb.

Abstract

The underlying mechanisms explaining brain volume changes in schizophrenia are not yet understood, but psychosis might be related to these changes. Forty-eight patients with first-episode schizophrenia underwent Magnetic Resonance Imaging brain scanning at inclusion and after five years. An association was found between longer duration of psychosis, larger gray matter volume decrease and larger ventricular volume increase. These findings strongly suggest that psychosis contributes to brain volume reductions found in schizophrenia.

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