Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 May;82(5):486-9.
doi: 10.1111/j.1349-7006.1991.tb01875.x.

Hereditary low level of plasma ceruloplasmin in LEC rats associated with spontaneous development of hepatitis and liver cancer

T Ono  1 , S Abe, M C Yoshida
Affiliations

Hereditary low level of plasma ceruloplasmin in LEC rats associated with spontaneous development of hepatitis and liver cancer

T Ono et al. Jpn J Cancer Res. 1991 May.

Abstract

Both young (5 weeks old) and old (61-100 weeks old) hereditary hepatitis LEC rats showed a markedly low level of plasma ceruloplasmin (Cp) ferroxidase activity as compared with that of age-matched LEA and BN strain rats. This trait was genetically examined by the use of (BN x LEC) F1 hybrid and (F1 x LEC) backcross rats. The F1 hybrids never developed hepatitis and showed a similar level of Cp to that found in the parental BN rats. Among the backcross rats with about 1:1 segregation rate for hepatitis, affected rats had a remarkably decreased level of Cp, as found in LEC rats, whereas unaffected rats exhibited a similar level of Cp to that of BN, F1 and LEA rats. These results indicate that the low level of Cp is heritable in a single autosomal recessive mode in LEC rats. The observed tight link between the low Cp level and the hepatitis in LEC rats suggests that defective copper metabolism may be associated with the occurrence of hepatitis in LEC rats, since Cp is a copper-binding protein primarily involved in copper transport from the liver.

PubMed Disclaimer

References

    1. ) Sasaki , M. , Yoshida , M. C. , Kagami , K. , Takeichi , N. , Kobayashi , H. , Dempo , K. and Mori , M.Spontaneous hepatitis in an inbred strain of Long‐Evans rats . Rat News Lett. , 14 , 4 – 6 ( 1985. ).
    1. ) Yoshida , M. C. , Masuda , R. , Sasaki , M. , Takeichi , N. , Kobayashi , H. , Dempo , K. and Mori , M.New mutation causing hereditary hepatitis in the laboratory rat . J. Hered. , 78 , 361 – 365 ( 1987. ). - PubMed
    1. ) Takeichi , N. , Kobayashi , H. , Yoshida , M. C. , Sasaki , M. , Dempo , K. and Mori , M.Spontaneous hepatitis in Long‐Evans rats. A potential animal model for fulminant hepatitis in man . Acta Pathol. Jpn. , 38 , 1369 – 1375 ( 1988. ). - PubMed
    1. ) Masuda , R. , Yoshida , M. C. , Sasaki , M. , Dempo , K. and Mori , M.High susceptibility to hepatocellular carcinoma development in LEG rats with hereditary hepatitis . Jpn. J. Cancer Res. , 79 , 828 – 835 ( 1988. ). - PMC - PubMed
    1. ) Masuda , R. , Yoshida , M. C. , Sasaki , M. , Dempo , K. and Mori , M.Hereditary hepatitis of LEG rats is controlled by a single autosomal recessive gene . Lab. Anim. , 22 , 166 – 169 ( 1988. ). - PubMed

Publication types

LinkOut - more resources