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Case Reports
. 2008 Dec 7;14(45):7009-11.
doi: 10.3748/wjg.14.7009.

Methotrexate induced sprue-like syndrome

Marta Maia Boscá  1 , Ramon Añón, Empar Mayordomo, Rosana Villagrasa, Nelly Balza, Cirilo Amorós, Juan Ramon Corts, Adolfo Benages
Affiliations
Case Reports

Methotrexate induced sprue-like syndrome

Marta Maia Boscá et al. World J Gastroenterol. .

Abstract

A 52 year-old male patient diagnosed of ankylosing spondylitis presented with an iron deficiency anemia after a ten-month treatment of methotrexate. He did not respond to treatment with oral iron not a proton pump inhibitor and an upper endoscopy was performed. The histological study of the duodenal biopsies showed villus atrophy. After removing the methotrexate, administering intramuscular iron and undertaking a gluten-free diet, the histological and analytical alterations progressively resolved.

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Figures

Figure 1
Figure 1
Biopsy of duodenum. A: Year 2003, (HE, × 40); B-C: Year 2003, (HE, × 100); D: Year 2005, (HE, × 40); E-F: Year 2005, (HE, × 100).
See this image and copyright information in PMC

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