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Randomized Controlled Trial
. 2008 May-Jun;55(3):103-11.

[Clinical symptom relief in obese patients with persistent moderate asthma secondary to decreased obesity]

[Article in Spanish]
Azael Hernández Romero  1 , Juan Matta Campos, Alejandra Mora Nieto, Leonel del Rivero, Atenea Estela Andrés Dionicio, Pilar Aguilar Ramírez, Carlos Barthell Solís, América García González, Leticia Carreta Macías, Ricardo Murguía Corral, Francisco Vázquez Nava, Víctor Manuel Almeida Arvizu
Affiliations
  • PMID: 19058489
Randomized Controlled Trial

[Clinical symptom relief in obese patients with persistent moderate asthma secondary to decreased obesity]

[Article in Spanish]
Azael Hernández Romero et al. Rev Alerg Mex. 2008 May-Jun.

Abstract

Background: The prevalence of asthma and obesity has increased last years implying important economical and social consequences. A relationship between asthma severity and obesity grade has been found. Therefore, it is necessary to evaluate if obesity decline has a beneficial impact on asthma severity.

Objective: To evaluate the effect of obesity decline on control symptoms and asthma severity.

Patients and methods: Ninety-six patients with obesity and moderate chronic asthma were randomized to group A or B and were maintained for 40 days on a low calorie diet. At baseline and at the end of the study, symptoms, measurement of obesity, spirometry, inflammatory cytokines and immunoglobulin's levels were assessed. Diets' safety was evaluated based on laboratory test. Data were analyzed with Student's t test.

Results: After 40 days on a low calorie diet, in group A, there were significant decreases of obesity (p < 0.001) and IgE, symptoms almost disappeared (cough persisted in 20%) and medication was suspended in 80%. Group B had obesity decline but IgE levels remained (> 100 UI/mL), symptoms and drug regimen remained unchanged. Both diets were not harmful for patients.

Conclusion: These results show that asthmatic obese patients maintained for 40 days on low calorie diet A, had obesity and IgE levels decrease and symptoms and asthma severity relief.

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