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. 2008 Dec;31(12):679-84.
doi: 10.1159/000173418. Epub 2008 Nov 20.

Prognostic factors of patients with ovarian yolk sac tumors: a study in Chinese patients

Xiaojing Tong  1 , Qi You, Liankun Li, Liying Cai, Chunyan Wang, Jianhua Zheng
Affiliations

Prognostic factors of patients with ovarian yolk sac tumors: a study in Chinese patients

Xiaojing Tong et al. Onkologie. 2008 Dec.

Abstract

Background: The aim of this study was to investigate the prognostic factors of ovarian yolk sac tumors (YST) and the survival rates in Chinese patients.

Patients and methods: We retrospectively reviewed 76 patients with ovarian YST from the Department of Obstetrics and Gynecology, Liaoning Cancer Hospital & Institute, China, between 1984 and 2007.

Results: Five-year overall survival rates in stages I, II, III, and IV were 91.8, 88.9, 39.5, and 25.0%, respectively. Age, histologic type, preoperative serum alpha-fetoprotein level, fertility-sparing surgery, tumor size and lymphadenectomy did not affect the prognosis of YST in our study. Multivariate analysis confirmed cisplatin-based chemotherapy (hazard ratio (HR) = 4.945), chemotherapy courses > 3 (HR = 2.954), residual tumor < or = 2 cm (HR = 0.224) and ascites volume < or = 100 ml (HR = 0.389) as independent predictors for overall survival.

Conclusions: Our study demonstrated that the 5-year overall survival rate of YST was 53.9% for the Liaoning Cancer Hospital & Institute, China. Cisplatin-based chemotherapy, chemotherapy courses, residual tumor size and ascites volume were independent prognosis factors.

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