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Review
. 2008 Dec;63(6):833-40.
doi: 10.1590/s1807-59322008000600021.

Operating room use of hypertonic solutions: a clinical review

Gustavo Azoubel  1 , Bartolomeu Nascimento, Mauricio Ferri, Sandro Rizoli
Affiliations
Review

Operating room use of hypertonic solutions: a clinical review

Gustavo Azoubel et al. Clinics (Sao Paulo). 2008 Dec.

Abstract

Hyperosmotic-hyperoncotic solutions have been widely used during prehospital care of trauma patients and have shown positive hemodynamic effects. Recently, there has been a growing interest in intra-operative use of hypertonic solutions. We reviewed 30 clinical studies on the use of hypertonic saline solutions during surgeries, with the majority being cardiac surgeries. Reduced positive fluid balance, increased cardiac index, and decreased systemic vascular resistance were the main beneficial effects of using hypertonic solutions in this population. Well-designed clinical trials are highly needed, particularly in aortic aneurysm repair surgeries, where hypertonic solutions have shown many beneficial effects. Examining the immunomodulatory effects of hypertonic solutions should also be a priority in future studies.

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References

    1. Mattox KL, Maningas PA, Moore EE, Mateer JR, Marx JA, Aprahamian C, et al. Prehospital hypertonic saline/dextran infusion for post-traumatic hypotension. The U.S.A. Multicenter Trial. Ann Surg. 1991;213:482–91. - PMC - PubMed
    1. Younes RN, Aun F, Accioly CQ, Casale LP, Szajnbok I, Birolini D. Hypertonic solutions in the treatment of hypovolemic shock: a prospective, randomized study in patients admitted to the emergency room. Surgery. 1992;111:380–5. - PubMed
    1. Vassar MJ, Perry CA, Holcroft JW. Prehospital resuscitation of hypotensive trauma patients with 7.5% NaCl versus 7.5% NaCl with added dextran: a controlled trial. J Trauma. 1993;34:622–32. discussion 632–3. - PubMed
    1. Auler JO, Jr, Pereira MH, Gomide-Amaral RV, Stolf NG, Jatene AD, Rocha e Silva M. Hemodynamic effects of hypertonic sodium chloride during surgical treatment of aortic aneurysms. Surgery. 1987;101:594–601. - PubMed
    1. Younes RN, Bechara MJ, Langer B, Aun F, Birolini D, Kuznieck S, et al. Use of a hypertonic solution of 7.5% NaCl in preventing post-declamping hypotension of the abdominal aorta. AMB Rev Assoc Med Bras. 1988;34:150–4. - PubMed

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