doi: 10.1111/j.1600-0714.1991.tb00422.x.
Effect of IFN-gamma on the expression of MHC class I and class II antigens in a human malignant oral epithelial cell line
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- PMID: 1906105
- DOI: 10.1111/j.1600-0714.1991.tb00422.x
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Effect of IFN-gamma on the expression of MHC class I and class II antigens in a human malignant oral epithelial cell line
J Oral Pathol Med.
1991 May.
Abstract
This study examined the expression of major histocompatibility complex (MHC) antigens in the KB human carcinoma cell line. MHC class I antigens (HLA-ABC and beta 2microglobulin) were constitutively expressed but not significantly enhanced by interferon-gamma (IFN-gamma). By contrast, MHC class II antigens were absent or expressed minimally on unstimulated KB cells, but DR and DP were significantly stimulated in a non-coordinated pattern (HLA-DR greater than -DP greater than -DQ) by IFN-gamma.
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