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. 1991 May;20(5):218-21.
doi: 10.1111/j.1600-0714.1991.tb00422.x.

Effect of IFN-gamma on the expression of MHC class I and class II antigens in a human malignant oral epithelial cell line

S Mutlu  1 , C Scully, S S Prime
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Effect of IFN-gamma on the expression of MHC class I and class II antigens in a human malignant oral epithelial cell line

S Mutlu et al. J Oral Pathol Med. 1991 May.

Abstract

This study examined the expression of major histocompatibility complex (MHC) antigens in the KB human carcinoma cell line. MHC class I antigens (HLA-ABC and beta 2microglobulin) were constitutively expressed but not significantly enhanced by interferon-gamma (IFN-gamma). By contrast, MHC class II antigens were absent or expressed minimally on unstimulated KB cells, but DR and DP were significantly stimulated in a non-coordinated pattern (HLA-DR greater than -DP greater than -DQ) by IFN-gamma.

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