Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2008 Dec 9;14(6):423-4.
doi: 10.1016/j.ccr.2008.11.005.

Kidney cancer: now available in a new flavor

William G Kaelin Jr  1
Affiliations
Free article
Comment

Kidney cancer: now available in a new flavor

William G Kaelin Jr. Cancer Cell. .
Free article

Abstract

The role of the von Hippel-Lindau tumor suppressor protein (pVHL) in kidney cancer has provided a rationale for treating this disease with hypoxia-inducible factor (HIF) antagonists. In this issue, Simon and coworkers show that the molecular signature of VHL(-/-) kidney cancers is profoundly influenced by whether they produce both HIF2alpha and HIF1alpha or HIF2alpha alone.

PubMed Disclaimer

Comment on

Substances

LinkOut - more resources