Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Jun;41(6):1241-4.
doi: 10.1016/j.biocel.2008.11.002. Epub 2008 Nov 17.

Oxidized phospholipids: biomarker for cardiovascular diseases

Mohammad Z Ashraf  1 , Niladri S Kar, Eugene A Podrez
Affiliations
Review

Oxidized phospholipids: biomarker for cardiovascular diseases

Mohammad Z Ashraf et al. Int J Biochem Cell Biol. 2009 Jun.

Abstract

Biologically active oxidized phospholipids can initiate and modulate many of the cellular events attributed to inflammation leading to atherosclerosis. Produced by enzymatic or non-enzymatic processes, these molecules interact with various cells via specific receptors and in general give rise to inflammatory signals. There is considerable evidence that oxidized phospholipids accumulate in vivo and play significant roles in atherosclerosis and thrombosis, suggesting that oxidized phospholipids could be biomarkers that reflect the global extent of these diseases in vivo. Thus, understanding the biosynthetic pathways, receptor specificity and signaling processes of oxidized phospholipids is important in understanding atherosclerosis, thrombosis and related inflammatory diseases.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Representative chemical structures of oxidized phospholipids formed during oxidation of PAPC.
Figure 2
Figure 2
Oxidized phospholipids present in oxidized LDL induce various inflammatory pathways leading to atherosclerosis.
See this image and copyright information in PMC

References

    1. Ashraf MZ, Kar NS, Chen X, Choi J, Salomon RG, Febbraio M, et al. Specific oxidized phospholipids inhibit scavenger receptor bi-mediated selective uptake of cholesteryl esters. J Biol Chem. 2008;283:10408–10414. - PMC - PubMed
    1. Berliner JA, Gharavi NM. Endothelial cell regulation by phospholipid oxidation products. Free Radic Biol Med. 2008;45:119–123. - PMC - PubMed
    1. Berliner JA, Watson AD. A role for oxidized phospholipids in atherosclerosis. N Engl J Med. 2005;353:9–11. - PubMed
    1. Bochkov VN, Kadl A, Huber J, Gruber F, Binder BR, Leitinger N. Protective role of phospholipid oxidation products in endotoxin-induced tissue damage. Nature. 2002;419:77–81. - PubMed
    1. Boullier A, Gillotte KL, Horkko S, Green SR, Friedman P, Dennis EA, et al. The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein. J Biol Chem. 2000;275:9163–9169. - PubMed

Publication types

LinkOut - more resources