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Review
. 2009 Jan;13(1):83-92.
doi: 10.1517/14728220802602349.

Protein kinase A as a biological target in cancer therapy

Silvio Naviglio  1 , Michele Caraglia, Alberto Abbruzzese, Emilio Chiosi, Davide Di Gesto, Monica Marra, Maria Romano, Annunziata Sorrentino, Luca Sorvillo, Annamaria Spina, Gennaro Illiano
Affiliations
Review

Protein kinase A as a biological target in cancer therapy

Silvio Naviglio et al. Expert Opin Ther Targets. 2009 Jan.

Abstract

Background: cAMP is a second messenger that plays a role in intracellular signal transduction of various stimuli. a major function of cAMP in eukaryotes is activation of cAMP-dependent protein kinase (PKA). PKA is the best understood member of the serine-threonine protein kinase superfamily, and is involved in the control of a variety of cellular processes. since it has been implicated in the initiation and progression of many tumors, PKA has been suggested as a novel molecular target for cancer therapy.

Objective/methods: Here, after describing some features of cAMP/PKA signaling that are relevant to cancer biology, we review targeting of PKA in cancer therapy, also discussing PKA as a biomarker for cancer detection and monitoring of therapy.

Results/conclusions: PKA is an increasingly relevant biological target in the therapy and management of cancer.

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