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. 1991 Jun;14(3):256-61.
doi: 10.1097/00002826-199106000-00010.

Concentrations of pravastatin and lovastatin in cerebrospinal fluid in healthy subjects

R E Botti  1 , J Triscari, H Y Pan, J Zayat
Affiliations

Concentrations of pravastatin and lovastatin in cerebrospinal fluid in healthy subjects

R E Botti et al. Clin Neuropharmacol. 1991 Jun.

Abstract

The capability of pravastatin and lovastatin, HMG-CoA reductase inhibitors likely to be taken chronically for hypercholesterolemia, to cross the blood-brain barrier was investigated in normal male volunteers. Lovastatin, which is lipophilic, was detected in cerebrospinal fluid (CSF) at concentrations that may have a pharmacologic effect. Pravastatin, which is hydrophilic, was not detected in CSF. It is concluded that pravastatin may have less potential for causing CNS-related side effects than lovastatin.

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Comment in

  • Pravastatin and lovastatin in cerebrospinal fluid.
    Triscari J, Markowitz JS, McGovern MW. Triscari J, et al. Clin Neuropharmacol. 1993 Dec;16(6):559-60. doi: 10.1097/00002826-199312000-00010. Clin Neuropharmacol. 1993. PMID: 9377592 Clinical Trial. No abstract available.

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