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Review
. 2009 Mar;40(3 Suppl):S86-7.
doi: 10.1161/STROKEAHA.108.533315. Epub 2008 Dec 8.

Subarachnoid hemorrhage: is it time for a new direction?

Julian Cahill  1 , John H Zhang
Affiliations
Review

Subarachnoid hemorrhage: is it time for a new direction?

Julian Cahill et al. Stroke. 2009 Mar.

Abstract

Background and purpose: Despite recent advances in the treatment of patients after subarachnoid hemorrhage, morbidity and mortality rates have failed to improve significantly. Although this was often blamed on vasospasm, is it time to consider alternative etiologies? Summary of Review- Early brain injury (EBI) is a recently described term that describes the immediate injury to the brain after subarachnoid hemorrhage. A number of pathways have been recognized as having a role in the etiology of EBI. This review provides a brief synopsis of EBI and its implications for the future.

Conclusions: EBI may be responsible for the detrimental effects seen in patients after subarachnoid hemorrhage. Additional studies are needed to determine the pathophysiology of EBI and to explore potential therapeutic options.

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Figures

Figure
Figure
Diagram summarizing some of the complex pathways and their interrelationships believed to be responsible for EBI. Inflammatory, apoptotic, and ischemic pathways all lead to cell death and EBI.
See this image and copyright information in PMC

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