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. 1991 May;35(5):1008-10.
doi: 10.1128/AAC.35.5.1008.

Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm

B Giwercman  1 , E T Jensen, N Høiby, A Kharazmi, J W Costerton
Affiliations

Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm

B Giwercman et al. Antimicrob Agents Chemother. 1991 May.

Abstract

Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth could be a major reason for the persistence of this sessile bacterium in chronic infections.

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References

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