Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Nov 25;5(11):e230.
doi: 10.1371/journal.pmed.0050230.

Bias, spin, and misreporting: time for full access to trial protocols and results

An-Wen Chan  1
Affiliations

Bias, spin, and misreporting: time for full access to trial protocols and results

An-Wen Chan. PLoS Med. .

Abstract

An-Wen Chan discusses the implications of a new study inPLoS Medicine that suggests that the randomized trial literature is skewed towards reporting favorable results.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: A-WC worked previously as a scientist with the World Health Organization's International Clinical Trials Registry Platform and currently chairs the SPIRIT initiative referenced in this article.

References

    1. McHenry LB, Jureidini JN. Industry-sponsored ghostwriting in clinical trial reporting: A case study. Account Res. 2008;15:152–167. - PubMed
    1. Jureidini JN, McHenry LB, Mansfield PR. Clinical trials and drug promotion: Selective reporting of study 329. Int J Risk Safety Med. 2008;20:73–81.
    1. Psaty BM, Kronmal RA. Reporting mortality findings in trials of rofecoxib for Alzheimer disease or cognitive impairment: A case study based on documents from rofecoxib litigation. JAMA. 2008;299:1813–1817. - PubMed
    1. Curfman GD, Morrissey S, Drazen JM. Expression of concern reaffirmed. N Engl J Med. 2006;354:1193. - PubMed
    1. Whittington CJ, Kendall T, Fonagy P, Cottrell D, Cotgrove A, et al. Selective serotonin reuptake inhibitors in childhood depression: Systematic review of published versus unpublished data. Lancet. 2004;363:1341–1345. - PubMed

MeSH terms