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. 2008 Dec 31;130(52):17676-7.
doi: 10.1021/ja806681z.

Versatile Pd(II)-catalyzed C-H activation/aryl-aryl coupling of benzoic and phenyl acetic acids

Dong-Hui Wang  1 , Tian-Sheng Mei, Jin-Quan Yu
Affiliations

Versatile Pd(II)-catalyzed C-H activation/aryl-aryl coupling of benzoic and phenyl acetic acids

Dong-Hui Wang et al. J Am Chem Soc. .

Abstract

The use of aryltrifluoroborates as coupling partners and O(2) as the oxidant substantially improves the scope and practicality of the Pd-catalyzed C-H activation/C-C coupling reaction. The newly discovered protocol made possible, for the first time, the ortho-coupling of electron-deficient arenes and phenyl acetic acids with organometallic reagents.

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Figures

Fig. 1
Fig. 1
Directed ortho-Metalation (DOM)
Fig. 2
Fig. 2
C-H Activation/Aryl-Aryl Coupling
See this image and copyright information in PMC

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